Urotensin Receptor
UT receptor
Urotensin receptor (UT) is a G-protein coupled receptor which binds the peptide hormoneurotensin. The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney, although they are found elsewhere, notably the central nervous system, at lower levels. The UT receptor produces potent but variable vasoconstrictor effects in some vascular beds, yet mediates vasodilation in others; it has also been implicated in osmoregulation.
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Urotensin Receptor Related Products (34)
Related Products (34)
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Palosuran
0 ImagesSynonyms: ACT-058362Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats.
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Urotensin II (114-124), human TFA
0 ImagesCat. No.: HY-P1164APurity: 98.10%Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
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Urotensin II-related peptide
0 ImagesUrotensin II-related peptide is a human urotensin II anague. Urotensin II-related peptide has high affinity for the UT receptor.
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PRL 2915
0 ImagesPRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM.
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SB-611812
0 ImagesSB-611812 is a urotensin II receptor (UTR) antagonist with the potential in the research of cardiovascular disease.
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SB-706375
0 ImagesSB-706375 is an antagonist of the Urotensin II (UII) receptor. By blocking the Urotensin II receptor, SB-706375 reduces the kidney's response to UII and Urotensin-related peptide (URP) and significantly increases the Glomerular Filtration Rate (GFR). SB-706375 can be used in research on kidney diseases and hypertension.
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SB-657510
0 ImagesSB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
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GSK 1562590 hydrochloride
0 ImagesGSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT.
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PRL 3195
0 ImagesCat. No.: HY-P4469CAS No.: 341519-04-8PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively).
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Urotensin II, mouse
0 ImagesCat. No.: HY-P1483CAS No.: 405137-01-1Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system.
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Urantide
0 ImagesCat. No.: HY-108055CAS No.: 669089-53-6Urantide is a selective and competitive urotensin-II (UT) receptor antagonist peptide (pKB=8.3) that blocks human urotensin-II (hU-II)-induced contractions in rat thoracic aorta ex vivo. Urantide can be used to study the (patho)physiological role of hU-II in the mammalian cardiovascular system.
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FL104
0 ImagesCat. No.: HY-10661CAS No.: 885672-81-1FL104 is a potent small molecule urotensin II receptor agonist with pEC50 of 7.11 for UTII receptor in R-SATTM assay.
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UPG-108
0 ImagesCat. No.: HY-P11258CAS No.: 3090686-88-4UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR). UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system.
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Urotensin II (114-124), human
0 ImagesCat. No.: HY-P1164CAS No.: 251293-28-4Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
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Palosuran hydrochloride
0 ImagesSynonyms: ACT-058362 hydrochloridePalosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats.
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SB-611812 (Standard)
0 ImagesCat. No.: HY-10664RCAS No.: 345892-71-9SB-611812 (Standard) is the analytical standard of SB-611812. This product is intended for research and analytical applications. SB-611812 is a urotensin II receptor (UTR) antagonist with the potential in the research of cardiovascular disease.
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Urotensin-II receptor antagonist-1
0 ImagesCat. No.: HY-10672CAS No.: 1034708-07-0Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 μM, CYP2D6; 1.4 μM, CYP3A4), inhibits κ-opioid receptor (EC50=3.2 μM), targets cardiac sodium channels (Ki=2.5 μM).
![[Orn5]-URP TFA](https://file.medchemexpress.com/product_pic/hy-p1167a.gif "Click to View [Orn5]-URP TFA Product Detail")
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